{"id":9754,"date":"2024-10-11T16:47:06","date_gmt":"2024-10-11T14:47:06","guid":{"rendered":"https:\/\/sygeplejevidenskab.dk\/?p=9754"},"modified":"2025-07-14T20:17:11","modified_gmt":"2025-07-14T18:17:11","slug":"effekt-af-kugledyne-paa-soevnloeshed-ved-depression-i-ambulant-psykiatri-et-randomiseret-crossover-studie","status":"publish","type":"post","link":"https:\/\/sygeplejevidenskab.dk\/index.php\/2024\/10\/11\/effekt-af-kugledyne-paa-soevnloeshed-ved-depression-i-ambulant-psykiatri-et-randomiseret-crossover-studie\/","title":{"rendered":"Effekt af kugledyne p\u00e5 s\u00f8vnl\u00f8shed ved depression i ambulant psykiatri: Et randomiseret crossover studie"},"content":{"rendered":"

\"\"<\/p>\n

Download som PDF<\/a><\/p>\n

Sanne Toft Kristiansen, Poul Videbech, Maria Speed, Philip Dionysopoulos, Merete Bender Bjerrum, Erik Roj Larsen. The efficacy of ball blankets on insomnia in depression in outpatient clinics: A randomized crossover multicentre trial; Journal of Sleep Research. Published 13 May 2024. <\/span>https:\/\/doi.org\/10.1111\/jsr.14238<\/a><\/p>\n

Introduktion
\n<\/span><\/strong>Depression rammer omkring 280 millioner mennesker globalt, og dens stigende udbredelse understreger behovet for effektiv forebyggelse og behandling. S\u00f8vnl\u00f8shed er et hyppigt ledsagesymptom ved depression og indeb\u00e6rer vanskeligheder med at falde i s\u00f8vn, opretholde s\u00f8vnen eller opn\u00e5 god s\u00f8vnkvalitet.<\/span><\/p>\n

Farmakologiske behandlinger kan medf\u00f8re bivirkninger og afh\u00e6ngighed. Protac Kugledynen\u00d2 er et muligt sikkert supplement eller alternativ, men der mangler beviser for dens effekt p\u00e5 s\u00f8vnl\u00f8shed hos voksne med depression. <\/span>Form\u00e5let<\/span> med dette studie var derfor at unders\u00f8ge kugledynens effekt p\u00e5 depressionsrelateret s\u00f8vnl\u00f8shed.<\/span><\/p>\n

Metode
\n<\/span><\/strong>Studiet var et randomiseret crossover-multicenterfors\u00f8g med 45 patienter med depression og s\u00f8vnl\u00f8shed, der sammenlignede Protac Kugledynen\u00d2 med en kontroldyne. Det prim\u00e6re udfald var \u00e6ndringer i total s\u00f8vntid (TST) m\u00e5lt ved aktigrafi. Sekund\u00e6re resultater var indsovningstid (SOL), antal opv\u00e5gninger (NA), v\u00e5genhed (WASO), daglig brug af p.n. beroligende medicin og sovemedicin, subjektiv s\u00f8vnkvalitet (PSQI), sv\u00e6rhedsgraden af s\u00f8vnl\u00f8shed (ISI), samt symptomer p\u00e5 depression (HAM-D6, MDI), symptomer p\u00e5 angst (BAI) og andre patientrapporterede udfald (SCL-28). Parrede tosidede t-test sammenlignede middelv\u00e6rdierne af forskellene i resultaterne.<\/span><\/p>\n

Resultater
\n<\/span><\/strong>Protac Kugledynen\u00d2 \u00f8gede TST med 12,9 minutter (CI95%:1,21-24,63, p=0,031) og reducerede HAM-D6 scoren med 2,78 (CI95%:-5,44;-0,11, p=0,042) og ISI scoren med 2,98 (CI95) -5,45; -0,50, p=0,020). Der blev ikke observeret signifikante \u00e6ndringer i SOL, NA, WASO, PSQI, MDI, BAI, SCL28 eller medicinforbrug.<\/span><\/p>\n

Diskussion
\n<\/span><\/strong>Selvom stigningen i TST p\u00e5 12,9 minutter var mindre end forventet, var den statistisk signifikant og klinisk relevant. Forbedringer i TST kan p\u00e5virke s\u00f8vnfaser som dyb s\u00f8vn, som ofte er reduceret hos deprimerede. Selvom polysomnografi ikke blev brugt til at m\u00e5le s\u00f8vnstadier i studiet, antyder forbedringer i ISI og HAM-D6 kliniske effekter.<\/span><\/p>\n

Konklusion
\n<\/span><\/strong>Protac Kugledynen\u00d2 forbedrede TST og reducerede depressive symptomer og sv\u00e6rhedsgraden af insomni, uden signifikante \u00e6ndringer i andre s\u00f8vnparametre, symptomer eller medicinforbrug.<\/span><\/p>\n

Implikationer for praksis
\n<\/span><\/strong>Protac Kugledynen\u00d2 kan v\u00e6re et gavnligt non-farmakologisk supplement til at forbedre s\u00f8vn ved depression.<\/span><\/p>\n

Fondsst\u00f8tte<\/strong>
\nStudiet er delvis finansieret af PROTAC A\/S, som ikke havde indflydelse p\u00e5 dets design, resultater, fortolkning og publicering heraf.<\/span><\/p>\n

Sanne Toft Kristiansen, Klinisk Sygeplejespecialist, RN, MCN, PhD. Mail: <\/span>sannkris@rm.dk <\/a>Poul Videbech, MD, DMSc, Professor. Mail: <\/span>poul.videbech@regionh.dk<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Download som PDF Sanne Toft Kristiansen, Poul Videbech, Maria Speed, Philip Dionysopoulos, Merete Bender Bjerrum, Erik Roj Larsen. The efficacy 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