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Download som PDF<\/a><\/p>\n The Aftermath of Intensive Care Delirium – A one-year follow-up focusing on mortality, health-related quality of life, cognitive function and patient experiences. Link: <\/span>Ph.d. afhandling<\/a> Introduktion Form\u00e5let med de tre studier Metode Resultater Konklusion Camilla Bekker Mortensen, klinisk sygeplejespecialist, MScHS, Ph.d., <\/span>Sj\u00e6llands Universitets Hospital, An\u00e6stesiologisk afdeling, Intensiv afsnit, K\u00f8ge<\/span><\/p>\n","protected":false},"excerpt":{"rendered":" N\u00e5r intensiv afdelinger behandler patienter med delirium, er det oftest med det antipsykotiske<\/p>\n","protected":false},"author":4,"featured_media":12782,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_ppp_document_settings_meta":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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\nMortality and HRQoL in ICU patients with delirium: protocol for 1-year follow-up of AID-ICU trial <\/span>DOI: <\/span>10.1111\/aas.13679<\/a>
\nLong-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with delirium <\/span>DOI: <\/span>10.1007\/s00134-023-07282-7<\/a>
\nStruggling to return to everyday life – the experiences of quality of life 1 year after delirium in the intensive care unit. <\/span>DOI:<\/span> 10.1111\/nicc.12939<\/a><\/p>\n
\n<\/span><\/strong>N\u00e5r intensiv afdelinger behandler patienter med delirium, er det oftest med det antipsykotiske l\u00e6gemiddel Haloperidol. Et stort randomiseret, blindet, placebo-kontrolleret studie (AID-ICU) med 1000 patienter viste i efter\u00e5ret 2022, <\/span>viste umiddelbart ingen effekt af Haloperidol, men man s\u00e5 en forskel ift. d\u00f8delighed favorisering behandling med Haloperidol hos akut kritisk syge patienter med delirium p\u00e5 Intensiv. I ph.d.-afhandlingen blev patienterne fulgt 1 \u00e5r senere og best\u00e5r af tre studier.<\/p>\n
\n<\/span>Studie 1:<\/span><\/strong> at unders\u00f8ge langtidsvirkning af Haloperidol i forhold d\u00f8delighed og helbredsrelateret livskvalitets hos akut kritisk syge patienter med delirium p\u00e5 intensiv afdeling
\n<\/span>Studie 2:<\/span><\/strong> at unders\u00f8ge langvirkning af Haloperidol i forhold til kognitiv funktion hos en gruppe udvalgte deltagere fra AID-ICU studiet.
\n<\/span>Studie 3:<\/span><\/strong> at unders\u00f8ge tidligere intensive patienters oplevelse af livet fra udskrivelse til et \u00e5r efter kritisk sygdom.<\/span><\/p>\n
\n<\/span><\/strong>Et \u00e5r efter blev patienternes vitale status unders\u00f8gt via nationale registre, og de patienter, som var i live, blev kontaktet via telefon og inviteret til at deltage i et studie vedr\u00f8rende deres helbredsrelaterede livskvalitet (studie 1). Yderligere blev en gruppe af danske patienter inviteret til at deltage i et studie, hvor deres kognitive funktion blev m\u00e5lt (studie 2). Sidst deltog en gruppe af disse patienter i et interview studie (studie 3).<\/span><\/p>\n
\n<\/span><\/strong>Forskellen i behandling med Haloperidol versus NaCl viste fortsat en signifikant forskel i d\u00f8deligheden hos patienter med delirium p\u00e5 Intensiv et \u00e5r senere, men havde ingen indflydelse p\u00e5 patienternes livskvalitet eller kognitiv funktion. I det kvalitative studie beskrev deltagerne, at livet efter kritisk sygdom var en kamp, hvor man skulle genvinde mange tabte funktioner, som b\u00e5de var af fysisk karakter, men ogs\u00e5 kognitivt samt et efterforl\u00f8b fyldt med mange udfordringer.<\/span><\/p>\n
\n<\/span><\/strong>Denne afhandling bidrager med yderligere viden om Haloperidols langtidsvirkning. Derudover har disse studier givet et indblik i et skr\u00f8beligt efterforl\u00f8b, hvor patienterne k\u00e6mper med flere udfordringer.<\/span><\/p>\n