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Ostuzzi G, Zaccoletti D, Mosconi C, Gastaldon C, et al. Comparison of antidepressant deprescribing strategies in individuals with clinically remitted depression: a systematic review and network meta-analysis. <\/span>The Lancet Psychiatry. 2026;13(1):24-36. <\/span>doi:10.1016\/S2215-0366(25)00330-X<\/a><\/p>\n Maj Siercke, ph.d., chefredakt\u00f8r og stifter af Sygeplejevidenskab.dk & Journal for Sygeplejevidenskab<\/span><\/em><\/p>\n Download som PDF<\/a><\/p>\n Introduktion Metode Resultater Diskussion Konklusion Implikationer for praksis L\u00c6S mere:<\/span><\/strong><\/p>\n Ostuzzi G, Zaccoletti D, Mosconi C, Gastaldon C, et al. Comparison of antidepressant deprescribing strategies in individuals with clinically remitted 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\n<\/span><\/strong>Langvarig behandling med antidepressiva er udbredt, og der mangler evidensbaserede strategier for, hvordan medicinen bedst trappes ud hos patienter med remitterende depression eller angst.<\/span><\/p>\n
\n<\/span><\/strong>Systematisk review og netv\u00e6rks-metaanalyse af 76 randomiserede kontrollerede studier med i alt 17.379 voksne med fuld eller delvis remission af depression eller angst under antidepressiv behandling. Studierne sammenlignede brat stop, hurtig (\u22644 uger) og langsom (>4 uger) udtrapning, dosisreduktion og fortsat behandling, med eller uden psykologisk st\u00f8tte. Prim\u00e6rt udfald var tilbagefald ved opf\u00f8lgningsslut.\u200b<\/span><\/p>\n
\n<\/span><\/strong>Resultaterne viste, at flere behandlingsstrategier med langsom aftrapning og psykologisk st\u00f8tte klart reducerer risikoen for tilbagefald sammenlignet med b\u00e5de pludseligt stop og hurtig nedtrapning af medicinen.<\/p>\n
\n<\/span><\/strong>Hos patienter med remitterende depression er langsom udtrapning kombineret med psykologisk st\u00f8tte lige s\u00e5 effektiv som fortsat antidepressiv behandling til at forebygge tilbagefald og bedre end abrupt eller hurtig seponering.<\/span><\/p>\n
\n<\/span><\/strong>Guidelines b\u00f8r fremme individualiseret udtrapning af antidepressiva med gradvis dosisreduktion og struktureret psykologisk st\u00f8tte hos patienter med remitteret depression, der \u00f8nsker at afslutte behandlingen.\u200b<\/span><\/p>\n
\n<\/span><\/strong>B<\/span>rat seponering og hurtig udtrapning frar\u00e5des. Planl\u00e6gning af udtrapning skal baseres p\u00e5 en langsom, individuelt tilpasset nedtrapning og patienterne skal tilbydes evidensbaseret psykologisk st\u00f8tte under udtrapningsforl\u00f8bet.\u200b<\/span><\/p>\n\n