{"id":19094,"date":"2025-08-29T18:11:51","date_gmt":"2025-08-29T16:11:51","guid":{"rendered":"https:\/\/sygeplejevidenskab.dk\/?p=19094"},"modified":"2025-08-29T18:21:29","modified_gmt":"2025-08-29T16:21:29","slug":"brugen-af-protonpumpehaemmere-i-danmark-2015-2023-viser-behov-for-rationel-ordination-og-plan-for-udtrapning","status":"publish","type":"post","link":"https:\/\/sygeplejevidenskab.dk\/index.php\/2025\/08\/29\/brugen-af-protonpumpehaemmere-i-danmark-2015-2023-viser-behov-for-rationel-ordination-og-plan-for-udtrapning\/","title":{"rendered":"Brugen af protonpumpeh\u00e6mmere i Danmark 2015-2023 -viser behov for rationel ordination og plan for udtrapning"},"content":{"rendered":"

\"\"<\/p>\n

Lundgaard KM, Christiansen M\u00d8, Sonne H, Mose K, Nyland N, Andersen MJL, Potteg\u00e5rd A. Trends in Proton-Pump Inhibitor Use Among Danish Adults: A Nationwide Drug Utilization Study 2015\u20132023. Basic & Clinical Pharmacology & Toxicology. 2025;137:e70057. doi: <\/span>10.1111\/bcpt.70057<\/a><\/p>\n

Af Karoline M. Lundgaard, Farmaceut, ph.d.-studerende. <\/span><\/em>kmlundgaard@health.sdu.dk<\/a><\/p>\n

Download Resume som pdf<\/a><\/p>\n

Resum\u00e9<\/span><\/strong><\/p>\n

Introduktion
\n<\/span><\/strong>Protonpumpeh\u00e6mmere (PPI\u2019er) er blandt de mest anvendte l\u00e6gemidler mod mavesyre-relaterede lidelser. P\u00e5 trods af deres dokumenterede effekt er der stigende bekymring for et muligt overforbrug og langvarig behandling uden klar indikation.<\/span><\/p>\n

Metode
\n<\/span><\/strong>Ved brug af landsd\u00e6kkende danske registre identificerede vi alle voksne danskere, der indl\u00f8ste mindst \u00e9n PPI-recept i perioden 2015-2023. Vi unders\u00f8gte antallet af nye brugere, total antal brugere, behandlingsvarighed og samtidig brug af l\u00e6gemidler der kan \u00f8ge risikoen for maves\u00e5r (fx blodfortyndende medicin).<\/span><\/p>\n

Resultater
\n<\/span><\/strong>I alt indl\u00f8ste 1,7 mio. voksne danskere mindst \u00e9n PPI-recept. Forbruget steg med 17 % i perioden. Den samlede andel af voksne danskere der brugte PPI steg fra 7,0 % i 2015 til 8,2 % i 2023. Antallet af nye brugere var stabil p\u00e5 omkring 3 nye brugere pr. 100 person\u00e5r. Pantoprazol var det mest anvendte PPI, mens rabeprazol n\u00e6sten ikke blev brugt. Tre \u00e5r efter behandlingsstart brugte 17 % fortsat PPI\u2019er, men kun 1,5 % var fortsat i alle tre uden behandlingspauser. Der var 50% i 2023 der samtidigt brugte medicin der kan give \u00f8get risiko for maves\u00e5r, en stigning p\u00e5 3,2 procentpoint siden 2015.<\/span><\/p>\n

Diskussion
\n<\/span><\/strong>Studiet viser en fortsat stigning i PPI-brugen i Danmark, men stigningen sker i et lavere tempo end tidligere \u00e5rtier. Den stabile incidens tyder p\u00e5, at flere forbliver i behandling, hvilket kan afspejle risiko for overforbrug.<\/span><\/p>\n

Konklusion
\n<\/span><\/strong>PPI-brugen blandt danske voksne er p\u00e5 et h\u00f8jt stabilt niveau og er tydeligt aldersafh\u00e6ngig. Selvom mange stopper behandlingen igen, forbliver en ikke ubetydelig andel i l\u00e6ngerevarende behandling.<\/span><\/p>\n

Implikationer for praksis
\n<\/span><\/strong>Resultaterne understreger behovet for fortsat fokus p\u00e5 rationel ordination og en plan for aftrapning af PPI\u2019er, is\u00e6r hos \u00e6ldre patienter.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Lundgaard KM, Christiansen M\u00d8, Sonne H, Mose K, Nyland N, Andersen MJL, Potteg\u00e5rd A. Trends in Proton-Pump Inhibitor Use Among […]<\/p>\n","protected":false},"author":1,"featured_media":12836,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_ppp_document_settings_meta":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false,"_members_access_role":[],"_members_access_error":""},"categories":[13,162],"tags":[],"class_list":["post-19094","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resume-af-forskning","category-sygdomsspecifikke-omraader-resume-af-forskning"],"acf":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/sygeplejevidenskab.dk\/wp-content\/uploads\/2024\/02\/Fordoejelse.png?fit=2000%2C2000&quality=80&ssl=1","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/posts\/19094","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/comments?post=19094"}],"version-history":[{"count":5,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/posts\/19094\/revisions"}],"predecessor-version":[{"id":19101,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/posts\/19094\/revisions\/19101"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/media\/12836"}],"wp:attachment":[{"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/media?parent=19094"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/categories?post=19094"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/tags?post=19094"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}