![\"\"](\"https:\/\/i0.wp.com\/sygeplejevidenskab.dk\/wp-content\/uploads\/2025\/03\/Resume-PHD-kvinde.png?resize=690%2C204&quality=80&ssl=1\")
<\/p>\n<\/p>\n
<\/p>\n
Lambert Max Norman Tandrup, Hu Lin Meng, Jeppesen Per Bendix.<\/span> A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women. Am J Clin Nutr 2017;106:801-11.<\/span> PMID: 28768649<\/span> DOI: <\/span>10.3945\/ajcn.116.151464<\/a><\/p>\n Download som PDF<\/a><\/p>\n Baggrund M\u00e5ls\u00e6tning Design Resultater Konklusion Forfattere Lambert Max Norman Tandrup, Hu Lin Meng, Jeppesen Per Bendix. A systematic review and meta-analysis of the effects of […]<\/p>\n","protected":false},"author":1,"featured_media":12675,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_ppp_document_settings_meta":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false,"_members_access_role":[],"_members_access_error":""},"categories":[13,162],"tags":[],"class_list":["post-12321","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resume-af-forskning","category-sygdomsspecifikke-omraader-resume-af-forskning"],"acf":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/sygeplejevidenskab.dk\/wp-content\/uploads\/2025\/03\/Kvindesygdomme.png?fit=2000%2C2000&quality=80&ssl=1","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/posts\/12321","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/comments?post=12321"}],"version-history":[{"count":1,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/posts\/12321\/revisions"}],"predecessor-version":[{"id":17202,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/posts\/12321\/revisions\/17202"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/media\/12675"}],"wp:attachment":[{"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/media?parent=12321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/categories?post=12321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sygeplejevidenskab.dk\/index.php\/wp-json\/wp\/v2\/tags?post=12321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n<\/span><\/strong>Aldersrelateret \u00f8strogenmangel f\u00f8rer til accelereret knogleresorption. Der er tegn p\u00e5, at isoflavoner gennem selektiv \u00f8strogenreceptor modulering kan ud\u00f8ve gavnlige virkninger mod \u00f8strogenmangel og knogletab. Isoflavon-aglykoner viser h\u00f8jere biotilg\u00e6ngelighed end deres glykosidiske modstykker og kan derfor have st\u00f8rre styrke.<\/span><\/p>\n
\n<\/span><\/strong>For at opsummere evidensen udf\u00f8rte vi en systematisk gennemgang og metaanalyse, der unders\u00f8gte isoflavon-behandlinger og tab af knoglemineralt\u00e6thed (BMD) hos peri- og postmenopausale kvinder.<\/span><\/p>\n
\n<\/span><\/strong>Vi s\u00f8gte systematisk i EMBASE og PubMed efter randomiserede kontrollerede fors\u00f8g (RCT’er), der evaluerer isoflavon-behandlinger til behandling af BMD-tab ved l\u00e6ndehvirvels\u00f8jlen og l\u00e5rbenshalsen hos kvinder med \u00f8strogenmangel. Der blev udf\u00f8rt separate metaanalyser med brug af modeller med tilf\u00e6ldige effekter for l\u00e6ndehvirvels\u00f8jlen og l\u00e5rbenshalsen for alle unders\u00f8gelser, der leverede isoflavoner som aglykoner.<\/span><\/p>\n
\n<\/span><\/strong>Seksogtyve RCT’er (n = 2652) blev inkluderet i metaanalysen. Ved l\u00e6ndehvirvels\u00f8jlen var isoflavon-behandling forbundet med en signifikant (P, 0,00001) h\u00f8jere v\u00e6gtet gennemsnitlig forskel (WMD) af BMD-\u00e6ndring p\u00e5 0,01 (95 % CI: 0,01, 0,02) end kontrollen. kontrolgruppen. For l\u00e5rbenshalsen (18 RCT’er, n = 1604) viste isoflavon-behandling en signifikant (P, 0,01) h\u00f8jere WMD for BMD-\u00e6ndring p\u00e5 \u00e6ndring p\u00e5 0,01 (95 % CI: 0,00, 0,02) sammenlignet med kontrolgruppen. <\/span>Ved at isolere studier, der giver isoflavon-aglykoner i deres behandlingsarm, var den gennemsnitlige effekt yderligere signifikant \u00f8get ved rygs\u00f8jlen (5 RCT’er, n = 682) til 0,04 (P, 0,00001; 95 % CI: 0,02, 0,05) og l\u00e5rbenshalsen (4 RCT’er, n = 524) til 0,03 (P , 0,05; 95 % CI: 0,00, 0,06) sammenlignet med kontrolgruppen. Denne beskyttende effekt mod knogletab forsvandt, n\u00e5r kun studier med formuleringer best\u00e5ende af overvejende isoflavon-glykosider blev inkluderet.<\/span><\/p>\n
\n<\/span><\/strong>Isoflavon-behandlinger ud\u00f8ver en moderat gavnlig effekt mod \u00f8strogenmangelbetinget knogletab hos kvinder. Effekten ser ud til at afh\u00e6nge af, om isoflavon-behandlinger er i aglykon form; vi konkluderer, at gavnlige virkninger mod knogletab kan v\u00e6re forbedret for isoflavon-aglykoner.<\/span><\/p>\n
\n<\/strong>Per Bendix Jeppesen, Associate Prof., PhD. Department of Clinical Medicine, Aarhus University<\/span> Department of Clinical Medicine, Aarhus University. <\/span>per.bendix.jeppesen@clin.au.dk<\/a>
\nMax NT Lambert, Adjunkt, Ph.D. Department of Clinical Medicine, Aarhus University, <\/span>Diabetes and Hormone Diseases – Medical Research Laboratory. <\/span>mntl@clin.au.dk<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"