![\"\"](\"https:\/\/i0.wp.com\/sygeplejevidenskab.dk\/wp-content\/uploads\/2025\/03\/Resume-PHD-kvinde.png?resize=690%2C204&quality=80&ssl=1\")
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Max Norman Tandrup Lambert, Anne Cathrine Thorup, Esben S\u00f8vs\u00f8 Szoscka Hansen, Per Bendix Jeppesen. Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms. Published: June 7, 2017. <\/span>https:\/\/doi.org\/10.1371\/journal.pone.0176590<\/a><\/p>\n Download som PDF<\/a><\/p>\n Baggrund Metode Resultat Der blev fundet et signifikant fald i 24 timers HFF (P < 0,01) og HFI (P < 0,05), n\u00e5r man sammenlignede \u00e6ndringen fra baseline til 12 m\u00e5neder med RCE (-4,3 HF\/24 timer, CI -6,8 til -2,3; -12956 \u03bcS s-1, CI -20175 til -5737) med placebo (0,79 HF\/24 timer, CI -1,56 til 3,15; 515 \u03bcS s-1, CI -5465 til 6496). 79 HF\/24 timer, CI -1,56 til 3,15; 515 \u03bcS s-1, CI -5465 til 6496). rHFF var ogs\u00e5 signifikant reduceret (P <0,05) i RCE-gruppen (-2,97 HFs\/d, CI -4,77 til -1,17) sammenlignet med placebo (0,036 HFs\/d, CI -2,42 til 2,49). Andre parametre var ikke-signifikante. RCE var veltolereret.<\/span><\/p>\n Konklusion Forfattere Max Norman Tandrup Lambert, Anne Cathrine Thorup, Esben S\u00f8vs\u00f8 Szoscka Hansen, Per Bendix Jeppesen. Combined Red Clover isoflavones and probiotics 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\n<\/span><\/strong>Naturlig \u00f8strogennedgang f\u00f8rer til vasomotoriske symptomer (VMS). Hormonbehandling lindrer symptomerne, men \u00f8ger kr\u00e6ftrisikoen. Der er behov for effektive behandlinger mod VMS med minimal kr\u00e6ftrisiko. Vi unders\u00f8gte virkningerne af en meget biotilg\u00e6ngelig aglykonrig r\u00f8dkl\u00f8ver-isoflavon behandling for at lindre eksisterende menopausale VMS, vurderet for f\u00f8rste gang ved 24-timers ambula-torisk hudkonduktans (SC).<\/span><\/p>\n
\n<\/span><\/strong>Vi gennemf\u00f8rte et parallelt, dobbeltblindet, randomiseret kontrolfors\u00f8g med 62 peri-menopausale kvinder i alderen 40-65 \u00e5r, som rapporterede \u2265 5 hedeture\/dag og follikelstimulerende hormon \u226535 IU\/L. Deltagerne fik enten to gange daglig behandling med biotilg\u00e6ngeligt RC-ekstrakt (RCE), der indeholder 34 mg\/d isoflavoner og probiotika, eller en maskeret placeboformulering i 12 uger.<\/span><\/p>\n
\n<\/span><\/strong>Det prim\u00e6re resultat var \u00e6ndring i daglig hedetursfrekvens (HFF) fra baseline til 12 uger ved hj\u00e6lp af 24-timers SC. Sekund\u00e6re resultater var \u00e6ndring i SC-bestemt hedetursintensitet (HFI), selvrapporteret HFF (rHFF) og hedeturs sv\u00e6rhedsgrad (rHFS), blodtryk og plasmalipider.<\/span><\/p>\n
\n<\/span><\/strong>Resultaterne tyder p\u00e5, at moderate doser af RCE var mere effektive og bedre end placebo til at reducere fysiologisk og selvrapporteret VMS. Resultaterne underst\u00f8tter, at objektive fysiologiske symptom-vurderingsmetoder b\u00f8r anvendes sammen med selvrapporteringsm\u00e5linger i fremtidige unders\u00f8gelser af VMS i overgangsalderen.<\/span><\/p>\n
\n<\/strong>Per Bendix Jeppesen, Associate Prof., PhD. Department of Clinical Medicine, Aarhus University<\/span> Department of Clinical Medicine, Aarhus University. <\/span>per.bendix.jeppesen@clin.au.dk<\/a>
\nMax NT Lambert, Adjunkt, Ph.D. Department of Clinical Medicine, Aarhus University, <\/span>Diabetes and Hormone Diseases – Medical Research Laboratory. <\/span>mntl@clin.au.dk<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"