![\"\"](\"https:\/\/i0.wp.com\/sygeplejevidenskab.dk\/wp-content\/uploads\/2025\/02\/Indlaeg-historien-bag-WHI.png?resize=380%2C380&quality=80&ssl=1\")
<\/p>\n<\/p>\n
Af Line Trier Friis og Mathilde Meedom Hermansen, stiftere af\u00a0HormoneHealthdk<\/a><\/p>\n Resume Endelig fik kvinder i menopause-transitionen opm\u00e6rksomhed i forskningen<\/strong>, da man I 1998 igangsatte man i USA et af de st\u00f8rste kliniske fors\u00f8g – et RCT-studie under navnet Women\u00b4s Health Initiative (WHI). Form\u00e5let med studiet var at afd\u00e6kke risici og fordele ved hormonterapi (HRT) hos post-menopausale kvinder ift. forebyggelse af kroniske sygdomme som fx hjerte-kar-sygdomme og kr\u00e6ft. Deltagerne blev delt i to grupper:<\/p>\n Gruppe 1: 16.608 kvinder med en livmoder, som fik \u00f8strogen og gestagen eller placebo I 2002 blev WHI- studiet afbrudt f\u00f8r tid og tiltrak sig hele verdens opm\u00e6rksomhed, da man i gruppe 1 s\u00e5 en \u00f8get risiko for udviklingen af brystkr\u00e6ft. Mange kvinder stoppede over natten deres hormonbehandling som en f\u00f8lge heraf.<\/p>\n WHI-studiet skabte overskrifter verden over<\/strong>, men kritikken af studiet har ikke f\u00e5et samme opm\u00e6rksomhed. Her er nogle vigtige kritikpunkter:<\/p>\n Anvendelsen af HRT er efterf\u00f8lgende faldet drastisk<\/strong> og er stadig p\u00e5 et lavt niveau. Dette p\u00e5 trods af kritikken af WHI-studiet samt at flere studier har givet et mere nuanceret billede af hormonterapi. WHI har medf\u00f8rt frygt for hormonterapi hos b\u00e5de kvinder og sundhedsfaglige. Mere end 20 \u00e5r efter mangler vi fortsat viden og svar p\u00e5 betydningen HRT-behandlingen af kvinder i menopause\u00e5rene. *For mere viden om hormonterapi, henviser vi til: Livsstil, pr\u00e6vention og behandling. <\/span>*For mere viden om post-menopause, henviser vi til: Peri- og menopause; kend dine symptomer<\/p>\n Vi h\u00e5ber du har f\u00e5et mere viden om WHI-studiet og er blevet nysgerrig p\u00e5 at vide mere. For mere indhold som dette, f\u00f8lg med her p\u00e5 sygeplejevidenskab samt p\u00e5 @hormonehealthdk instagram: https:\/\/www.instagram.com\/hormonehealthdk\/<\/a>\u00a0 og LinkedIn profil: https:\/\/www.linkedin.com\/company\/105738448\/<\/a><\/p>\n Kilder Writing Group for the Women\u2019s Health Initiative Investigators, 2002. Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women. Principal Results From the Women\u2019s Health Initiative Randomized Controlled Trial, JAMA, \u00e5rg. 288, nr. 3, s. 321\u2013333.<\/p>\n","protected":false},"excerpt":{"rendered":" Historien bag WHI \u2013 studiet der sendte hormonbehandling af kvinder i menopause-transitionen i skammekrogen Af Line Trier Friis og Mathilde […]<\/p>\n","protected":false},"author":1,"featured_media":11890,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_ppp_document_settings_meta":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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\n<\/strong>WHI-studiet fra 1998 unders\u00f8gte hormonterapi* (HRT) hos post-menopausale kvinder*, men blev afbrudt i 2002 p\u00e5 grund af \u00f8get risiko for brystkr\u00e6ft. Studiet har skabt frygt for HRT, selvom kritikken af studiet og nyere forskning giver et mere nuanceret billede. Der mangler stadig viden om HRT’s betydning for kvinder i overgangsalderen.<\/p>\n
\nGruppe 2: 10.739 kvinder uden en livmoder, som fik \u00f8strogen eller placebo.<\/span><\/p>\n\n
\n<\/strong>Mosconi, L., 2024. The Menopause Brain. New York: Penguin Random House<\/p>\n